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Updated: Mar 2, 2026
qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
Published on: March 6, 2019
Association between the killer cell immunoglobulin-like receptor a haplotype and childhood acute lymphoblastic
Awad E Osman1, Abdullah AlJuryyan1, Hanan Alharthi1
1Pathology and Clinical Laboratory Management, King Fahad Medical City, Riyadh 11525, Saudi Arabia.
Abstract:
Killer immunoglobulin-like receptors (KIRs) have the ability to regulate natural killer (NK) cell function through inhibition/activation mechanisms. Healthy human cells express HLA class I ligands on their surface, which are recognized by NK cells to avoid spontaneous cell destruction. The associations of KIRs and/or HLA class 1 ligands in leukemic patients have been studied in some populations, with some of these studies demonstrating an association of specific types with leukemia. KIRs and their corresponding HLA class 1 ligands were investigated in Saudi patients with ALL and AML and compared to healthy controls. The homozygous A haplotype was found significantly more often in ALL patients ≤18years-old than in control individuals. No significant association was observed in KIRs and their corresponding HLA ligands in this study.
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