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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Overview of solidification techniques for self-emulsifying drug delivery systems from industrial perspective
J Mandić1, A Zvonar Pobirk2, F Vrečer3
1Krka, d.d., Novo mesto, Šmarješka cesta 6, 8000 Novo mesto, Slovenia.
International Journal of Pharmaceutics
|May 23, 2017
Summary
Solidifying liquid self-emulsifying drug delivery systems (SEDDS) into solid dosage forms enhances drug stability and patient compliance. This review covers industrially viable techniques and excipients for creating solid SEDDS with high yields.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Formulation Development
Background:
- Self-emulsifying drug delivery systems (SEDDS) are lipid-based formulations designed to enhance the solubility and oral bioavailability of poorly soluble drugs.
- Traditionally, liquid SEDDS are encapsulated in soft or hard capsules, which can present challenges in handling and stability.
Purpose of the Study:
- To review industrially applicable techniques for transforming liquid SEDDS into solid dosage forms.
- To discuss suitable excipients and processing parameters for solid SEDDS production.
- To highlight methods that ensure high production yield and scalability.
Main Methods:
- Review of various solidification techniques including powder, granule, pellet, and tablet formation.
- Analysis of excipient selection and their role in processability and self-emulsification.
- Evaluation of processing parameters critical for successful transformation.
Main Results:
- Solid dosage forms of SEDDS offer improved stability, handling, and patient compliance compared to liquid formulations.
- Successful solidification requires careful selection of excipients and processing conditions to maintain self-emulsifying properties.
- Various techniques like spray drying, granulation, and direct compression can be employed.
Conclusions:
- Transforming liquid SEDDS into solid dosage forms is a key strategy for improving drug delivery.
- Industrial applicability and scalability are achievable with appropriate solidification techniques and excipient choices.
- Solid SEDDS represent a promising approach for enhancing the therapeutic potential of poorly bioavailable drugs.
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