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Published on: May 5, 2016
Kinetics of biofilm formation by Staphylococcus lugdunensis strains in bone and joint infections
Xavier Argemi1, Gilles Prévost2, Philippe Riegel2
1Hôpitaux Universitaires, Maladies Infectieuses et Tropicales, Strasbourg, France; Université de Strasbourg, CHRU de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), VBP EA7290, Institut de Bactériologie, 3 Rue Koeberlé, Strasbourg, France.
Objective:
To describe the clinical presentation and 1-year follow-up of patients with bone and joint infections (BJIs) caused by Staphylococcus lugdunensis and evaluate its biofilm-forming capacities.
Patients And Methods:
Overall, 28 patients with BJIs from VISLISI clinical trials were included. We evaluated 1-year clinical follow-up and analyzed biofilm production kinetics of the 28 strains using the BioFilm Ring Test®.
Results:
Of all patients, 12 had osteoarticular infections without material and 16 had prosthetic joint infections, of which 9 underwent a 1-stage revision procedure. At the 1-year follow-up, all patients were cured but needed a surgical intervention. Diabetes affected 46.4% of all patients. Of all, 20 strains (71.4%) started biofilm formation within 2 h, but all strains started the formation after 4 h experiment, and 25 strains (89.3%) reached a maximum after 6 h.
Conclusions:
This study describes the clinical and surgical management of BJIs caused by S. lugdunensis and shows that 1-stage prosthesis exchange procedures may be efficient. Further, It shows that biofilm production by this strain was not marginal and directly impacted clinical and surgical management.
