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Updated: Mar 2, 2026

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
Published on: November 17, 2023
Autologous Platelet-rich Fibrin Matrix in Non-healing Trophic Ulcers in Patients with Hansen's Disease
Umashankar Nagaraju1, Priya K Sundar1, Priyanka Agarwal1
1Department of Dermatology, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.
Background:
Non-healing trophic ulcers in Hansen's disease patients is one of the major causes for disability. It has been shown that autologous platelet-rich fibrin matrix (PRFM) is effective in healing chronic non-healing leg ulcers.
Aim:
The objective of this study is to demonstrate the efficacy of autologous platelet-rich fibrin matrix (PRFM) in non-healing trophic ulcers in patients treated for Hansen's disease.
Design:
A prospective study.
Setting:
An institution-based clinic.
Participants:
Seven treated patients with Hansen's disease, with a mean age of 38.33 years, with nine non-healing trophic ulcer of more than 6 weeks duration.
Measurements:
Photographs were taken before treatment and at every subsequent sitting. Area and volume were calculated at baseline and every subsequent sitting till the closure was achieved.
Materials And Methods:
The healthy ulcers were treated with PRFM at weekly intervals, repeated once a week for a maximum of five sittings as per requirement.
Results:
The mean percentage improvement in the area was 93.52%, and volume was 97.74% at the end of the second sitting. All ulcers closed by a maximum of five sittings. No adverse events were noted.
Conclusion:
PRFM for the treatment of trophic ulcers in treated patients with Hansen's disease is a feasible, safe, simple and inexpensive method.
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