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The Bioenhancer Piperine is at Least Trimorphic
Laura Y Pfund1, Brianna L Chamberlin1, Adam J Matzger1
1Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
Crystal Growth & Design
|May 23, 2017
Summary
Polymer-induced heteronucleation discovered two new piperine forms with better solubility. These novel polymorphs could enhance piperine
Area of Science:
- Materials Science, Crystallography, Pharmaceutical Science
Background:
- Piperine, a bioenhancer, suffers from low solubility, limiting its efficacy.
- Discovering new crystalline forms (polymorphs) can improve drug properties.
Purpose of the Study:
- To discover novel piperine polymorphs using polymer-induced heteronucleation (PIHn).
- To evaluate the solubility and structural characteristics of the new polymorphs.
Main Methods:
- Utilized polymer-induced heteronucleation (PIHn) for crystalline polymorph discovery.
- Performed structural comparison and stability analysis of the identified piperine forms.
Main Results:
- Identified two novel piperine polymorphs.
- Both new forms exhibit enhanced solubility compared to the commercial piperine polymorph.
- π-π interactions were observed in the new forms but not the commercial one.
Conclusions:
- PIHn is effective for discovering new polymorphs of low-solubility compounds like piperine.
- The novel piperine polymorphs show potential for improved bioenhancer efficacy due to increased solubility.
- Despite extended conjugation, π-π interactions are not favored in the solid state for piperine.
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