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Pancreatic neuroendocrine tumors: the basics, the gray zone, and the target

Dionysia Kelgiorgi1, Christos Dervenis2

  • 1Department of Surgery, Euroclinic Athens, Athens, Greece.

F1000Research
|May 23, 2017
PubMed

Keywords:
islet cell tumourspanNETspancreatic neuroendocrine tumors

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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