Related Experiment Video
Updated: Mar 2, 2026
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
935
Identifying the association between interleukin-6 and lichen planus: A meta-analysis
Meng Yin1, Guifeng Li2, Hui Song1
1School of Dentistry, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, Shandong 250014, P.R. China.
Biomedical Reports
|May 23, 2017
Summary
Interleukin-6 (IL-6) may play a role in oral lichen planus (OLP) pathogenesis, particularly in Asian populations. This meta-analysis found elevated IL-6 levels in OLP patients, suggesting a potential link requiring further investigation.
Area of Science:
- Immunology
- Dermatology
- Oral Medicine
Background:
- Lichen planus (LP) and oral lichen planus (OLP) are inflammatory conditions with complex pathogenesis.
- Interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in various diseases.
- Previous studies suggest a link between IL-6 and LP/OLP, but a systematic analysis is lacking.
Purpose of the Study:
- To systematically evaluate the association between interleukin-6 (IL-6) levels and the pathogenesis of lichen planus (LP) / oral lichen planus (OLP).
- To perform a meta-analysis of existing case-control studies to precisely assess this association.
Main Methods:
- A meta-analysis was conducted on case-control studies published up to December 2015.
- Studies were identified from PubMed, Embase, and China National Knowledge Infrastructure databases.
- Pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated for IL-6 expression.
Main Results:
- Eight studies were included, involving 299 LP/OLP cases and 231 controls.
- A significant pooled mean difference for IL-6 was observed (MD = 16.24, 95% CI: 9.84-22.64).
- Subgroup analysis revealed significantly increased IL-6 expression in Asian LP/OLP patients but not in Caucasian patients.
Conclusions:
- Interleukin-6 (IL-6) may be significantly involved in the pathogenesis of lichen planus (LP).
- The association appears stronger in Asian populations compared to Caucasian populations.
- Further research is warranted to validate the role of IL-6 in LP pathogenesis.
Related Concept Videos
01:24T Cell Types and Functions
2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
01:20The JAK-STAT Signaling Pathway
13.4K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.4K