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Advancements in Developing Strategies for Sterilizing and Functional HIV Cures
Wei Xu1, Haoyang Li1, Qian Wang1
1Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China.
Biomed Research International
|May 23, 2017
Summary
Eradicating latent HIV reservoirs is key to an HIV cure. Research is advancing towards sterilizing or functional cures by targeting HIV latency in CD4+ T cells.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Combined antiretroviral therapy (cART) has significantly improved lifespan and reduced mortality in individuals with human immunodeficiency virus (HIV).
- Persistent HIV latency in memory CD4+ T cells poses a major obstacle to achieving a complete HIV cure.
- Current HIV cure strategies aim for either a sterilizing cure (complete provirus elimination) or a functional cure (long-term viral control without treatment).
Purpose of the Study:
- To review recent advancements in the field of HIV cure research.
- To discuss future prospects and challenges in developing effective HIV cures.
- To provide an overview of strategies targeting HIV latency.
Main Methods:
- Literature review of recent scientific publications on HIV cure strategies.
- Analysis of progress in understanding and targeting latent HIV reservoirs.
- Discussion of different approaches for sterilizing and functional HIV cures.
Main Results:
- Significant progress has been made in understanding HIV latency mechanisms.
- Various innovative strategies are being explored to eliminate or control latent HIV.
- The review highlights key breakthroughs and ongoing research directions.
Conclusions:
- Achieving a sterilizing or functional HIV cure remains a complex challenge.
- Continued research into targeting latent HIV reservoirs is crucial.
- The development of novel therapeutic approaches holds promise for future HIV cure strategies.
