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Updated: Mar 2, 2026

Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans
Published on: February 27, 2012
Caenorhabditis elegans: An important tool for dissecting microRNA functions
Ziwen Zhu1, Duo Zhang1, Heedoo Lee1
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, USA.
Abstract:
Caenorhabditis elegans (C. elegans), a member of the phylum Nematoda, carries the evolutionarily conserved genes comparing to mammals. Due to its short lifespan and completely sequenced genome, C. elegans becomes a potentially powerful model for mechanistic studies in human diseases. In this mini review, we will outline the current understandings on C. elegans as a model organism for microRNA (miRNA)-related research in the pathogenesis of human diseases.
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