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Updated: Mar 2, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.9K
[BULLOUS PEMPHIGOID RESISTANT TO CORTICOSTEROIDS]
Mohammad Sah1, Dganit Rozenman1, Eran Cohen1
1Department of Dermatology, Ha'Emek Medical Center, Afula, Israel.
Harefuah
|May 23, 2017
Summary
This case report details a 65-year-old female with bullous pemphigoid resistant to corticosteroids. Treatment with cyclophosphamide led to complete recovery, highlighting a rare dermatologic presentation.
Area of Science:
- Dermatology
- Autoimmune Bullous Diseases
Background:
- Bullous pemphigoid is the most common autoimmune bullous disease.
- Standard treatment involves corticosteroids, but resistance can occur.
Observation:
- A 65-year-old female presented with a generalized bullous rash diagnosed as bullous pemphigoid.
- Initial treatment with high-dose systemic corticosteroids (prednisone 100mg/day for 8 weeks) showed no improvement and symptom worsening.
Findings:
- The patient was diagnosed with corticosteroid-resistant bullous pemphigoid after a normal adrenocorticotropic hormone stimulation test.
- Switching to cyclophosphamide resulted in immediate symptom improvement and complete recovery.
Implications:
- Corticosteroid resistance in bullous pemphigoid is rare but important to recognize in dermatology.
- This case suggests cyclophosphamide as an effective alternative treatment for such resistant cases.
- Prompt diagnosis and alternative treatment strategies are crucial for managing corticosteroid-resistant bullous pemphigoid.
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