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Gastrointestinal Histoplasmosis: A Case Series.
Rashi Sharma1, Lipika Lipi1, Smeeta Gajendra1
11 Medanta-The Medicity, Gurgaon, Haryana, India.
International Journal of Surgical Pathology
|May 23, 2017
Summary
Histoplasmosis is a fungal infection that can affect the gastrointestinal tract. Early diagnosis and treatment of gastrointestinal histoplasmosis are crucial for patient survival and preventing fatal outcomes.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Gastroenterology
Background:
- Histoplasmosis, caused by Histoplasma capsulatum, is an invasive fungal infection.
- It commonly affects immunocompromised individuals but can occur in others.
- Disseminated disease can involve multiple organs, including the gastrointestinal tract.
Purpose of the Study:
- To report cases of gastrointestinal histoplasmosis diagnosed via colonic biopsies.
- To highlight the clinical presentation and diagnostic challenges of this condition.
- To emphasize the importance of early diagnosis and treatment for improved prognosis.
Main Methods:
- Retrospective study of colonic biopsies.
- Histopathological examination for diagnosis.
- Review of patient data from January 2014 to December 2015.
Main Results:
- Five cases of colonic histoplasmosis were diagnosed.
- Patients presented with symptoms like diarrhea and gastrointestinal bleeding.
- Delayed diagnosis in two cases led to fatal outcomes, while others responded to treatment.
Conclusions:
- Gastrointestinal histoplasmosis requires prompt diagnosis through histopathology.
- Early and aggressive treatment significantly improves survival rates.
- Untreated disease carries a high mortality risk.
