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Related Experiment Video

Updated: Mar 2, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

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[RADIOSURGERY FOR PITUITARY ADENOMAS].

Or Cohen-Inbar1,2,3,4

  • 1Department of Neurological Surgery, Rambam Health Care Center, Haifa Israel.

Harefuah
|May 23, 2017
PubMed
Summary
This summary is machine-generated.

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Radiation dose to neuroanatomical structures of pituitary adenomas and the effect of Gamma Knife radiosurgery on pituitary function.

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Radiosurgery offers excellent tumor control for pituitary adenomas, but endocrine remission rates vary by tumor type. Long-term follow-up is crucial due to potential late recurrences after treatment.

Area of Science:

  • Neurosurgery
  • Endocrinology
  • Radiation Oncology

Background:

  • Pituitary adenomas are common intracranial tumors with diverse clinical presentations.
  • Treatment options include surgery, medication, radiation, and observation.
  • Radiosurgery is often used as an adjunctive therapy for residual or recurrent pituitary adenomas.

Purpose of the Study:

  • To review radiosurgery outcomes for various pituitary adenoma types.
  • To compare tumor control rates with endocrine remission rates.
  • To identify factors influencing treatment success and complications.

Main Methods:

  • Comprehensive literature review of radiosurgery series for pituitary adenomas.
  • Analysis of data for nonfunctioning, ACTH-secreting, GH-secreting adenomas, and prolactinomas.

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  • Evaluation of radiographic tumor control and endocrine biochemical remission rates.

    • Main Results:

    • Excellent radiographic tumor control (approx. 90%) for nonfunctioning adenomas.
    • Lower endocrine remission rates compared to tumor control for functioning adenomas.
    • Higher doses improve endocrine remission but increase complication risk; Cushing's disease shows highest remission, prolactinomas the lowest.

    Conclusions:

    • Radiosurgery is effective for pituitary adenoma tumor control, but endocrine remission requires higher doses and varies by tumor subtype.
    • Delayed hypopituitarism and cranial neuropathies are the most common complications.
    • Long-term clinical and radiographic follow-up is essential due to the possibility of late recurrences.