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Updated: Mar 2, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Qualitative Estimation of Drug Entrapment Efficiency in Polymeric Nano - Micelles Using Dissipative Particle Dynamics
Farzin Hadizadeh1, Jamal Shamsara2
1Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 91775-1365, Iran.
Background:
Dissipative particle dynamics (DPD) is a simulation method that has one of its applications in the field of pharmaceutical science and drug delivery.
Objective:
DPD is employed to study morphology and some other characteristics of polymeric nanomicelles. Two systems were considered in this study: system A which includes curcumin, Polycaprolactone (PCL), Polyethylene glycol (PEG) and water beads and system B which includes paclitaxel, Polylactic acid (PLA), PEG and water beads.
Method:
In this study we focused on the simulation of drug entrapment in polymeric micelles using DPD method.
Results:
Results indicated that the qualitative comparison of polymeric-micelles with different compositions, after carefully tuning input parameters and simulation conditions, can be successfully performed using DPD.
Conclusion:
Considering real state of a system for DPD simulation will have a great impact on the reliability of the simulation results.
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