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Allopurinol prevents ischaemia-dependent haemorheological changes
P L Capecchi1, F L Pasini, A L Pasqui
1Istituto di Patologia Medica, Università di Siena Le Scotte, Italy.
European Journal of Clinical Pharmacology
|January 1, 1988
Summary
Allopurinol pre-treatment significantly improves blood viscosity and filterability after exercise-induced ischemia. This effect is linked to reduced free radical formation, not direct action on neutrophils.
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Ischemia during exercise can negatively impact blood rheology.
- Xanthine oxidase contributes to free radical formation, potentially worsening ischemia effects.
- Peripheral obliterative arterial disease (POAD) patients may exhibit altered responses to interventions.
Purpose of the Study:
- To investigate the effect of allopurinol pre-treatment on hemorheological parameters following exercise-induced ischemia.
- To determine if allopurinol affects serum oxidase activity and neutrophil function.
- To elucidate the mechanism by which allopurinol influences blood viscosity and filterability.
Main Methods:
- Administration of allopurinol prior to exercise and ischemia.
- Measurement of blood viscosity (BV) and whole blood filterability (WBF).
- Assay of serum oxidase activity and in vitro neutrophil function tests.
Main Results:
- Allopurinol pre-treatment attenuated exercise-induced deterioration in BV and WBF.
- A reduction in exercise-induced serum oxidase activity was observed, though less pronounced in POAD patients.
- Allopurinol showed no effect on in vitro hemorheological parameters or neutrophil responses.
Conclusions:
- Allopurinol effectively mitigates hemorheological changes post-ischemia.
- The protective effect of allopurinol is likely mediated by inhibiting xanthine oxidase-dependent free radical formation in tissues.
- Allopurinol's efficacy may be influenced by disease states like POAD.