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Related Experiment Video

Updated: Mar 2, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.

M Saint-Cricq1, J Carrete1, C Gaboriaud2

  • 1Université Grenoble Alpes, CEA LITEN , F-38000 Grenoble, France.

Nano Letters
|May 23, 2017
PubMed
Summary

The complement protein C1q can disperse large carbon nanotubes (CNTs) but not small ones, according to atomistic computations and experiments. This binding has implications for nanomaterial applications.

Keywords:
C1qCarbon nanotubesfree energymolecular dynamicssolvationtoxicity

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Area of Science:

  • Biophysics
  • Materials Science
  • Immunology

Background:

  • The complement protein C1q plays a crucial role in the immune system.
  • Carbon nanomaterials, including carbon nanotubes (CNTs) and graphene, have diverse biomedical applications.
  • Understanding the interaction between biological molecules and nanomaterials is essential for safe and effective use.

Purpose of the Study:

  • To atomistically compute the binding free energy between the C1q globular domain and carbon nanomaterials.
  • To investigate the potential of C1q to disaggregate and disperse CNTs.
  • To explore the implications of C1q-nanomaterial interactions for biomedical applications.

Main Methods:

  • Atomistic free energy computations were performed to model the binding of C1q to CNTs and graphene.
  • Computational predictions were validated through experimental observations.
  • The study focused on the interaction of the C1q globular domain with multiwalled and single-walled CNTs of varying diameters.

Main Results:

  • C1q demonstrates strong binding to carbon nanomaterials.
  • C1q was found to effectively disaggregate and disperse large-diameter multiwalled CNTs.
  • C1q showed limited ability to disperse thin single-walled CNTs.

Conclusions:

  • The binding interaction between C1q and CNTs is significant and dependent on CNT diameter and structure.
  • C1q's ability to disperse certain CNTs opens possibilities for their use in biomedical applications.
  • Further research into C1q-nanomaterial interactions can advance our understanding of immune responses and nanomedicine.