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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Mar 2, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Peripartum depression: Early recognition improves outcomes.

Margaret M Howard1,2, Niharika D Mehta3,4, Raymond Powrie5,6

  • 1Departments of Psychiatry and Human Behavior and Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.

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This summary is machine-generated.

Maternal depression is common in women of childbearing age, particularly after childbirth. Treating depression during pregnancy and breastfeeding is often safer than leaving it untreated, benefiting mother and baby.

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Area of Science:

  • Reproductive psychiatry
  • Perinatal mental health

Background:

  • Postpartum depression affects many women of childbearing age.
  • Untreated maternal depression poses risks to mother, fetus, and infant.

Purpose of the Study:

  • To review the evidence on treating depression in pregnant and breastfeeding women.
  • To inform clinical practice regarding antidepressant use in this population.

Main Methods:

  • Literature review of studies on maternal depression and antidepressant treatment.
  • Analysis of risks versus benefits of pharmacologic interventions.

Main Results:

  • Evidence suggests risks of untreated depression may exceed those of antidepressant treatment.
  • Caution is advised, but treatment is often warranted.

Conclusions:

  • Early recognition and treatment of maternal depression are crucial.
  • Pharmacologic treatment can be beneficial when risks are carefully considered.