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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
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Chronic constipation: Update on management.

Umar Hayat1, Mohannad Dugum2, Samita Garg3,4

  • 1Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

Cleveland Clinic Journal of Medicine
|May 23, 2017
PubMed
Summary
This summary is machine-generated.

Managing chronic constipation requires addressing secondary causes, lifestyle adjustments, and various therapies. New pharmacologic treatments are emerging for this common gastrointestinal condition.

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Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Chronic constipation is a prevalent gastrointestinal disorder impacting quality of life.
  • Effective management necessitates a comprehensive approach, including identifying secondary causes.

Purpose of the Study:

  • To outline current strategies for managing chronic constipation.
  • To highlight recent advancements and future directions in pharmacologic therapies.

Main Methods:

  • Review of existing literature and clinical guidelines.
  • Analysis of newly approved and investigational drugs for constipation.

Main Results:

  • Management involves a stepwise approach: secondary cause identification, lifestyle modifications, and pharmacologic/non-pharmacologic therapies.
  • Several novel pharmacologic agents have recently gained approval, with more in development.

Conclusions:

  • Current management strategies for chronic constipation are multifaceted.
  • The pipeline of new drugs offers promising advancements for patients with chronic constipation.