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Risperidone in Elderly Schizophrenic Patients: An Open-Label Trial.

Ileana Berman¹, Amalia Merson¹, Julia Rachov-Pavlov¹

¹Harvard Medical School.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry

|May 23, 2017

Summary

Risperidone safely improved schizophrenia symptoms and cognition in elderly patients. Further research is recommended for this vulnerable population.

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Area of Science:

Geriatric Psychiatry
Pharmacology

Background:

Elderly patients with chronic schizophrenia often experience behavioral disturbances.
Limited research exists on atypical antipsychotics in this demographic.

Purpose of the Study:

To assess the safety and efficacy of risperidone in elderly patients with chronic schizophrenia and behavioral disturbances.
To evaluate the impact of risperidone on psychiatric and cognitive symptoms.

Main Methods:

A small group of elderly patients (N=10) with chronic schizophrenia received risperidone.
Safety was monitored through physical examinations.
Efficacy was assessed by changes in schizophrenic symptoms and cognitive performance.

Main Results:

No clinically significant adverse physical effects were observed.
Significant improvements in schizophrenic symptoms were noted.
Cognitive performance also showed improvement during risperidone treatment.

Conclusions:

Risperidone appears to be safe and effective for managing chronic schizophrenia and behavioral disturbances in elderly patients.
The positive outcomes warrant a larger, double-blind study to confirm these findings.