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Valproic Acid for Physically Aggressive Behavior in Geriatric Patients.

William D Sandborn1, Fernando Bendfeldt1, Ronald Hamdy1

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The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|May 23, 2017
PubMed
Summary
This summary is machine-generated.

Valproic acid showed some effectiveness in managing aggressive behavior in dementia patients. However, additional medications and significant side effects were often necessary for adequate control.

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Area of Science:

  • Geriatric Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Aggressive behavior is a common and challenging symptom in geriatric patients with dementia.
  • Effective pharmacological interventions are needed to manage behavioral disturbances in this population.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of valproic acid in managing physically aggressive behavior in elderly dementia patients.

Main Methods:

  • Retrospective case series of four geriatric patients with dementia experiencing physically aggressive behavior.
  • Treatment involved the administration of valproic acid.
  • Subsequent addition of second medications was noted if initial treatment was insufficient.

Main Results:

  • Valproic acid demonstrated improvement in aggressive behavior in most of the studied geriatric patients.
  • A significant proportion of patients required the addition of a second medication for optimal behavioral management.
  • Notable side effects associated with valproic acid treatment were observed.

Conclusions:

  • Valproic acid may offer partial benefit for aggression in dementia, but often necessitates combination therapy.
  • The significant side effect profile warrants careful consideration and monitoring in clinical practice.