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Related Experiment Videos

A possible role for ferritin during inflammation.

S Brailsford1, J Lunec, P Winyard

  • 1Dept of Rheumatology, Medical School, Birmingham.

Free Radical Research Communications
|January 1, 1985
PubMed
Summary

Extracellular ferritin, an iron storage protein, stimulates neutrophil superoxide production during inflammation. This suggests a key role for serum ferritin in host defense against bacterial infections by enhancing oxidative metabolism.

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Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Background:

  • Inflammation triggers increased production of the iron storage protein, (apo)ferritin, in the liver.
  • This (apo)ferritin is released into the bloodstream, acting as an acute phase protein.
  • The precise biological function of elevated serum (apo)ferritin levels remains unclear.

Purpose of the Study:

  • To investigate the biological significance of extracellular (apo)ferritin.
  • To determine if serum (apo)ferritin influences neutrophil function.

Main Methods:

  • Neutrophil superoxide production was measured.
  • Experiments were conducted in the presence of cytochalasin B.
  • (Apo)ferritin was added across a range of physiological concentrations.

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Main Results:

  • Extracellular (apo)ferritin was observed to stimulate superoxide production from neutrophils.
  • This effect occurred in the presence of cytochalasin B.
  • The stimulation was concentration-dependent within a physiological range.

Conclusions:

  • Extracellular ferritin likely plays a significant role in host defense mechanisms.
  • It contributes to combating bacteraemia by stimulating neutrophil oxidative metabolism.