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Updated: Mar 2, 2026
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
Published on: October 23, 2015
Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a
M Araújo1, R Viveiros2, A Philippart3
1Colorobbia España S.A, Carretera CV-160, 12192 Vilafamés, España; Ce.Ri.Col, Centro Richerche Colorobbia, Via Pietramarina 123, 50053 Sovigliana (FI), Italy.
Abstract:
In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of >2.5. Furthermore, ibuprofen was successfully loaded on this coating, allowing a controlled drug release of the anti-inflammatory agent.
