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Updated: Mar 2, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Host-directed therapies offer novel opportunities for the fight against tuberculosis
Arnaud Machelart1, Ok-Ryul Song1, Eik Hoffmann1
1University of Lille, CHU Lille, Institut Pasteur de Lille, INSERM U1019, CNRS UMR 8204, Center for Infection and Immunity of Lille (CIIL), F-59000 Lille, France.
Abstract:
Tuberculosis (TB) remains a leading global health problem that is exacerbated by the emergence of multidrug and extensively drug-resistant Mycobacterium tuberculosis strains. Control of the disease requires novel therapeutic strategies. Modulating host homeostasis appears to be a promising approach, and recent studies have identified novel potential host targets and compounds that could be investigated for host-directed therapies (HDTs). Moreover, the recent development of intracellular high-throughput phenotypic assays makes it possible to screen large libraries of compounds to identify more rapidly new effectors for mycobacterial elimination. Technological advances combined with the novel HDT concept opens an interesting and promising research area that could ultimately deliver personalized TB treatment.
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