Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Diversity of Protists II

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...

Infection

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prevalence of multiple human intestinal parasites across diverse environments in Madagascar.

PLoS neglected tropical diseases·2026

Same author

Clinical pathology and laboratory medicine capacity across a sample of Malawian institutions: a cross-sectional survey.

American journal of clinical pathology·2026

Same author

Analysis of anatomic pathology and laboratory medicine diagnostic services and infrastructure available at a sample of institutions in Kenya.

American journal of clinical pathology·2025

Same author

Survey of anatomic and clinical pathology services and infrastructure in Nigeria.

American journal of clinical pathology·2024

Same author

Survey of clinical microbiology and infectious disease testing capabilities among institutions in Africa.

American journal of clinical pathology·2024

Same author

Technology and Future of Multi-Cancer Early Detection.

Life (Basel, Switzerland)·2024

Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026

Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026

Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026

Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026

Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026

Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 2, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Malaria Pathogenesis.

Danny A Milner¹

¹Harvard T.H. Chan School of Public Health, American Society for Clinical Pathology, Center for Global Health, Chicago, Illinois 60603.

Cold Spring Harbor Perspectives in Medicine

|May 24, 2017

Summary

This summary is machine-generated.

Malaria parasites exhibit diverse life cycle stages and population sizes. Human disease arises from parasite biology interacting with host responses, influenced by various factors.

More Related Videos

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

Related Experiment Videos

Last Updated: Mar 2, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

Area of Science:

* Malariology
* Parasitology
* Human Infectious Diseases

Background:

* Six Plasmodium species infect humans, causing malaria.
* Parasites undergo complex life cycles with multiple morphological stages and population dynamics.
* Most malaria infections are asymptomatic, with clinical disease manifesting in a subset of patients.

Purpose of the Study:

* To elucidate the complex interplay between malaria parasite biology and human host responses in disease development.
* To identify factors contributing to the variation in malaria clinical presentation.

Main Methods:

* Review of the Plasmodium parasite life cycle and replication within mosquito and human hosts.
* Analysis of the host-parasite interactions leading to clinical malaria symptoms.
* Examination of contributing factors to disease variability.

Main Results:

* Malaria parasites display over 10 morphological states and replicate extensively within hosts.
* Clinical malaria symptoms (fever, anemia, coma) result from parasite biology and human pathophysiology.
* Parasite genetic diversity, coinfections, comorbidities, treatment delays, host genetics, and environment modulate disease.

Conclusions:

* Malaria pathogenesis is a complex interaction between parasite and host, not solely dependent on parasite load.
* Understanding these interactions is crucial for managing malaria and developing effective interventions.
* Variability in host-parasite dynamics explains the spectrum of malaria disease, from asymptomatic to severe.