Complexity of bone marrow hematopoietic stem cell niche
Noboru Asada1,2, Shoichiro Takeishi3,4, Paul S Frenette5,6,7
1Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY, 10461, USA. nasada@okayama-u.ac.jp.
International Journal of Hematology
|May 24, 2017
Summary
Hematopoietic stem cells (HSCs) reside in bone marrow niches, regulated by perivascular cells. These cells are crucial for HSC maintenance, mobilization, and the development of blood cancers.
Area of Science:
- Hematology
- Stem Cell Biology
- Microenvironment Research
Background:
- Hematopoietic stem cells (HSCs) are essential for lifelong blood cell production.
- HSCs reside in specialized bone marrow (BM) niches for regulation.
- Recent advances allow investigation of BM niche components.
Purpose of the Study:
- To review recent advances in HSC niche research.
- To focus on the role of perivascular cells in HSC maintenance and mobilization.
- To discuss the microenvironment's role in malignant hematopoietic diseases.
Main Methods:
- Review of recent scientific literature.
- Analysis of studies on molecular deletion in BM cells.
- Focus on perivascular cell function.
Main Results:
- Perivascular stromal cells are key components of the HSC niche.
- These cells play significant roles in HSC maintenance and mobilization.
- The BM microenvironment is implicated in the emergence of blood cancers.
Conclusions:
- Perivascular cells are critical regulators of HSC function within the niche.
- Understanding the HSC niche is vital for both normal hematopoiesis and disease.
- Further research into the microenvironment's role in hematologic malignancies is warranted.
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