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Recent perspectives of management of breast cancer metastasis - an update
Qingzhong Tian1, Yun Wang, Hao Guo
1Department of Oncological Surgery 2, Xuzhou City Central Hospital, the affiliated Hospital of the Southeast University Medical School (Xu zhou), the Tumor Research Institute of the Southeast University (Xu zhou), Xuzhou Jiangsu 221009, China.
Abstract:
Breast cancer is the leading cause of cancer related deaths in women and one of the most common cancers globally. The major obstacle in the management of breast cancer, especially at advanced stages, is metastasis. Metastasis in the advanced stages of breast cancer could decrease survival to approximately 5 years. The reasons could include lack of targeted receptors or chemotherapeutic agents for the management of advanced-stage breast cancer metastasis. The new emerging avenues for the management of this deadly pathological state include local manipulations like radiofrequency ablation (RFA), microwave thermotherapy, cryosurgery (cryotherapy), chemoembolization, radioembolization, breast surgery, or metastasectomy. Few single-institution reports showed improved survival in selected patients like those with oligometastatic stage IV breast cancer. The present review article focused on these emerging new multimodality treatment approaches for a possible efficient management.
Insights
Advanced breast cancer metastasis significantly reduces survival. Emerging multimodality treatments like radiofrequency ablation and cryosurgery offer new hope for managing this deadly condition.
Area of Science:
- Oncology
- Surgical Oncology
- Interventional Radiology
Background:
- Breast cancer is a leading cause of cancer deaths in women worldwide.
- Metastasis in advanced breast cancer presents a major management challenge, often leading to a 5-year survival rate.
- Limited targeted therapies exist for advanced-stage breast cancer metastasis.
Purpose of the Study:
- To review emerging multimodality treatment approaches for advanced-stage breast cancer metastasis.
- To explore novel local therapeutic interventions for improved patient outcomes.
Main Methods:
- Review of current literature on local ablative and interventional therapies.
- Focus on radiofrequency ablation (RFA), microwave thermotherapy, cryosurgery, chemoembolization, radioembolization, and metastasectomy.
- Analysis of single-institution reports on oligometastatic stage IV breast cancer.
Main Results:
- Emerging local treatments show promise in managing breast cancer metastasis.
- Selected patients, particularly those with oligometastatic stage IV disease, may experience improved survival with these approaches.
- Multimodality strategies are being investigated for more efficient management.
Conclusions:
- Novel local interventional and ablative techniques represent a promising frontier in advanced breast cancer management.
- These emerging therapies, especially in combination, may offer improved survival benefits for patients with metastatic disease.
- Further research and clinical trials are warranted to optimize these multimodality treatment strategies.
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