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Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt-DNA crosslinking
Khushbu Singh1, Swati Singh, Payal Srivastava
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India. akpatra@iitk.ac.in.
Chemical Communications (Cambridge, England)
|May 24, 2017
Abstract:
Two highly luminescent water-soluble heterometallic LnPt2 complexes, [{cis-PtCl(NH3)2}2Ln(L)(H2O)](NO3)2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from EuIII or TbIII observed through confocal fluorescence microscopy.
