Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

68.1K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamical modeling of individual sensory reactivity and habituation learning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

ERK inhibits Capicua repressor function via multisite phosphorylation.

Journal of cell science·2026
Same author

Optogenetic control of transition to metamorphosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Tissue maps in motion.

Nature methods·2025
Same author

Disrupted developmental signaling induces novel transcriptional states.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A model for boundary-driven tissue morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Mar 2, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.0K

Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.

Miriam Osterfield1, Celeste A Berg2, Stanislav Y Shvartsman3

  • 1Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Developmental Cell
|May 24, 2017
PubMed
Summary
This summary is machine-generated.

Investigating developmental biology, this study uses the Drosophila egg chamber to explore how signaling pathways and patterning control tissue formation across evolutionary scales. Findings offer insights applicable to diverse organisms.

Keywords:
Drosophilacomputational modelingdorsal appendageeggshellepitheliaevolutionfollicular epitheliummorphogenesisoogenesispatterning

More Related Videos

Upright Imaging of Drosophila Egg Chambers
12:29

Upright Imaging of Drosophila Egg Chambers

Published on: March 13, 2015

8.2K
Drosophila Pupal Abdomen Immunohistochemistry
08:29

Drosophila Pupal Abdomen Immunohistochemistry

Published on: October 2, 2011

16.8K

Related Experiment Videos

Last Updated: Mar 2, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.0K
Upright Imaging of Drosophila Egg Chambers
12:29

Upright Imaging of Drosophila Egg Chambers

Published on: March 13, 2015

8.2K
Drosophila Pupal Abdomen Immunohistochemistry
08:29

Drosophila Pupal Abdomen Immunohistochemistry

Published on: October 2, 2011

16.8K

Area of Science:

  • Developmental biology
  • Cellular and molecular biology
  • Evolutionary biology

Background:

  • Understanding tissue and organ formation necessitates integrating knowledge across multiple biological scales.
  • Signaling pathways and developmental patterning are key regulators of morphogenesis and cell fate specification.
  • The Drosophila egg chamber offers a model system to study conserved developmental mechanisms.

Purpose of the Study:

  • To elucidate the mechanisms of tissue and organ formation by examining signaling pathways and patterning.
  • To investigate how these processes are conserved across evolutionary scales.
  • To develop and apply quantitative modeling tools for understanding development.

Main Methods:

  • Utilizing the Drosophila egg chamber as a model system.
  • Investigating the intersection of Epidermal Growth Factor (EGF) and Bone Morphogenetic Protein (BMP) signaling pathways.
  • Employing quantitative modeling approaches.

Main Results:

  • Demonstrated how EGF and BMP signaling intersect to specify cell types for epithelial tube formation.
  • Revealed connections between different scales of development, including evolutionary scales.
  • Fostered the development of quantitative modeling tools for developmental studies.

Conclusions:

  • The Drosophila egg chamber provides a tractable system for understanding fundamental principles of development.
  • Principles derived from this model are applicable to diverse developmental processes across organisms.
  • Integrated approaches across scales are crucial for advancing developmental biology.