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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

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Related Experiment Video

Updated: Mar 2, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

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Nervous System Development: Temporal Patterning of Large Neural Lineages.

¹Department of Clinical and Experimental Medicine, Linkoping University, SE-581 85 Linkoping, Sweden.

Current Biology : CB

|May 24, 2017

Summary

Neural progenitor cells generate diverse cell types in a specific birth order. This study reveals a regulatory network controlling temporal cell diversification in Drosophila neural lineages.

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Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Neural progenitor cells (NPCs) generate diverse neuronal and glial subtypes.
Cell fate decisions during neurodevelopment often follow a temporal progression, or birth order.

Purpose of the Study:

To identify the regulatory network governing temporal cell diversification in large neural lineages.
To understand the mechanisms of sequential cell-type generation by NPCs.

Main Methods:

Utilized the Drosophila central nervous system as a model system.
Employed genetic and molecular techniques to investigate gene regulatory networks.

Main Results:

Identified an expanding network of transcription factors and signaling pathways.
Demonstrated the role of this network in orchestrating the birth order of distinct neural cell types.
Characterized the temporal dynamics of gene expression underlying lineage progression.

Conclusions:

The temporal diversification of neural lineages is controlled by a complex, context-dependent regulatory network.
Understanding this network provides insights into the fundamental principles of neurodevelopmental patterning.
This work elucidates conserved mechanisms of cell-fate determination in the nervous system.