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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Bipolar postpartum depression: An update and recommendations.

Verinder Sharma1, Minakshi Doobay2, Christine Baczynski3

  • 1Western University & Parkwood Institute - London, Ontario, Canada.

Journal of Affective Disorders
|May 24, 2017
PubMed
Summary
This summary is machine-generated.

Bipolar postpartum depression (PPD) is common and distinct from unipolar PPD. Prompt identification and treatment are crucial for effective management, with specific mood stabilizers recommended over antidepressants.

Keywords:
BipolarDepressionDiagnosisDrugsPeripartumPostpartumPrevalencePsychotherapyScreeningTreatment

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Area of Science:

  • Reproductive Psychiatry
  • Mood Disorders
  • Perinatal Mental Health

Background:

  • Growing interest in bipolar postpartum depression (PPD).
  • Unanswered questions regarding prevalence, screening, clinical features, and treatment of bipolar PPD.
  • Need for clear diagnostic and therapeutic guidelines.

Purpose of the Study:

  • To review the current literature on bipolar postpartum depression.
  • To delineate its prevalence, clinical characteristics, and treatment strategies.
  • To emphasize the importance of early diagnosis and intervention.

Main Methods:

  • Comprehensive literature search of MEDLINE/PubMed, PsycINFO, and Cochrane Database.
  • Keywords included bipolar, depression, postpartum, prevalence, screening, diagnosis, and treatment.
  • Inclusion of all relevant English-language articles.

Main Results:

  • Bipolar disorder (BD) diagnosed in 21.4-54% of women with PPD.
  • Key features: early onset, postpartum onset, atypical/psychotic/mixed symptoms, family history of BD.
  • Recommended treatments: lithium, quetiapine, lamotrigine; avoid antidepressants due to mania risk.

Conclusions:

  • Bipolar PPD is prevalent and distinguishable from unipolar PPD.
  • Timely identification is essential for appropriate treatment.
  • Future research should focus on acute and preventative pharmacotherapy and psychotherapy for bipolar PPD.