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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Roles of Electrolytes: Calcium and Phosphate01:27

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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Phosphate in Chronic Kidney Disease Progression.

Mario Cozzolino, Denis Foque, Paola Ciceri

    Contributions to Nephrology
    |May 24, 2017
    PubMed
    Summary

    High serum phosphate (P) levels, even within the normal range, are linked to increased mortality risk in both healthy individuals and chronic kidney disease (CKD) patients. P overload may accelerate aging and reduce survival expectancy.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Metabolic Diseases

    Background:

    • Serum phosphate (P) levels show a direct association with mortality.
    • Elevated P concentrations, even within normal ranges, correlate with adverse outcomes in general and CKD populations.
    • Experimental data suggest P overload contributes to vascular, skeletal, and renal aging, impacting survival.

    Purpose of the Study:

    • To investigate the association between serum phosphate levels and mortality.
    • To explore the impact of P overload on survival expectancy and aging processes.
    • To highlight challenges in assessing P balance, especially in declining renal function.

    Main Methods:

    • Review of existing literature on serum phosphate levels and mortality.
    • Analysis of experimental data on P overload effects.

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  • Discussion of methodologies for P balance assessment in human physiology.

    • Main Results:

    • A direct and independent link exists between serum P levels and mortality.
    • High P concentrations are associated with unfavorable outcomes in both healthy subjects and CKD patients.
    • P overload is implicated in accelerating vascular, skeletal, and renal aging.

    Conclusions:

    • Serum phosphate levels are a significant predictor of mortality.
    • Accurate assessment of phosphate balance is challenging, particularly in CKD patients.
    • Further research is needed to clarify phosphate metabolism and its clinical implications.