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Hepatocellular carcinoma in a child with familial Russell-Silver syndrome
D Chitayat1, J M Friedman, L Anderson
1University of British Columbia Clinical Genetics Unit, Grace Hospital, Vancouver, B.C., Canada.
American Journal of Medical Genetics
|December 1, 1988
Abstract:
We describe a 4-year-old boy with Russell-Silver syndrome (RSS) found to have hepatocellular carcinoma. The brother of this child also had manifestations of RSS. This is the third malignancy and the first hepatocellular carcinoma described in a patient with RSS. The coexistence of hepatocellular carcinoma and RSS may be completely fortuitous; however, the known association of liver cancer with growth abnormality and hemihypertrophy, findings also present in RSS, suggest that these disorders may be related.