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Dose warping performance in deformable image registration in lung.

Shunsuke Moriya1, Hidenobu Tachibana2, Nozomi Kitamura3

  • 1Radiological Sciences, Graduate Division of Health Sciences, Komazawa University, Tokyo 1548525, Japan.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|May 25, 2017
PubMed
Summary

An in-house deformable image registration (DIR) system showed comparable accuracy to commercial systems for lung cancer radiotherapy. However, significant dose errors were observed in some cases, highlighting the need for careful validation of DIR tools.

Keywords:
Deformable image registrationFour-dimensional computed tomographyGeneralized equivalent uniform doseLung cancer

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Area of Science:

  • Medical Physics
  • Radiotherapy
  • Image Processing

Background:

  • Deformable image registration (DIR) is crucial for accurate dose accumulation in lung cancer radiotherapy.
  • Spatial accuracy of DIR does not always reflect the impact on deformed dose distribution.

Purpose of the Study:

  • To compare the dosimetric accuracy of an in-house DIR system (NiftyReg) with commercial systems (MIM Maestro, Velocity AI).
  • To evaluate the impact of DIR on dose distribution within the gross tumor volume (GTV).

Main Methods:

  • 19 non-small-cell lung cancer patients' 4DCT images were registered using three DIR systems.
  • Deformation vector fields (DVFs) were computed and used to deform GTV and dose distributions.
  • Agreement was assessed using generalized equivalent uniform dose (gEUD), mean dose (Dmean), and 3D gamma index.

Main Results:

  • Most patients showed good agreement (<3% difference) for Dmean and gEUD.
  • The Velocity system showed significant errors (up to 50.1% for gEUD, 11.8% for Dmean) in two patients.
  • Gamma index analysis revealed statistically significant differences between DIR systems.

Conclusions:

  • A finely tuned in-house DIR system can achieve accuracy comparable to commercial systems.
  • Caution is advised due to potential significant dose errors (>5% Dmean, >30% gEUD) even with commercial DIR tools.