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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

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Radiation-associated peritoneal angiosarcoma.

Chin Jin Seo¹, Sze Min Lek², Grace Hwei Ching Tan³

¹Singapore General Hospital, Singapore, Singapore.

BMJ Case Reports

|May 25, 2017

Summary

Peritoneal angiosarcoma is a rare cancer presenting with variable symptoms, making diagnosis challenging. This case highlights diagnostic difficulties and limited treatment options for this rare soft tissue sarcoma.

Keywords:

Cancer intervention Surgical oncology

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Area of Science:

Oncology
Pathology

Background:

Angiosarcomas are rare soft tissue sarcomas, typically affecting the head and neck.
Peritoneal angiosarcoma is exceptionally rare, with limited reported cases and variable presentations.
Diagnosis is often delayed due to nonspecific symptoms.

Observation:

A patient presented with hemorrhagic ascites 17 years post-radiotherapy for endometrial cancer.
Imaging and biopsy confirmed peritoneal angiosarcoma.
The disease was extensive, precluding surgical intervention.

Findings:

The patient received palliative chemotherapy for advanced peritoneal angiosarcoma.
Despite treatment, the patient's condition worsened, leading to a fatal outcome.
This case underscores the diagnostic challenges and poor prognosis associated with peritoneal angiosarcoma.

Implications:

Highlights the importance of considering rare diagnoses in patients with a history of radiotherapy and ascites.
Emphasizes the need for improved diagnostic strategies for peritoneal angiosarcoma.
Underscores the limited therapeutic options and poor outcomes for advanced peritoneal angiosarcoma, necessitating further research into effective treatments.