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Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Related Experiment Video

Updated: Mar 2, 2026

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Published on: December 9, 2022

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[Skeletal muscle stem cell.]

Shinsuke Yuasa1

  • 1Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Clinical Calcium
|May 25, 2017
PubMed
Summary

Granulocyte-colony stimulating factor receptor (G-CSFR) is crucial for skeletal muscle regeneration. Its expression increases after injury, and G-CSF treatment enhances muscle repair in mice.

Area of Science:

  • Muscle stem cell biology
  • Regenerative medicine
  • Molecular signaling in muscle repair

Background:

  • Adult skeletal muscle contains satellite cells, a stem cell population essential for repair.
  • Satellite cell activation, proliferation, and differentiation are key to recovering muscle function after injury.

Purpose of the Study:

  • To identify factors that promote myocyte differentiation.
  • To investigate the role of granulocyte-colony stimulating factor receptor (G-CSFR) in skeletal muscle regeneration.

Main Methods:

  • Screening for myocyte differentiation-promoting factors.
  • Analyzing G-CSFR expression in skeletal muscle development and after injury.
  • Evaluating the effect of exogenous G-CSF on muscle regeneration in a mouse injury model.

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Isolating Stem Cells from Soft Musculoskeletal Tissues
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Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

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Related Experiment Videos

Last Updated: Mar 2, 2026

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

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Isolating Stem Cells from Soft Musculoskeletal Tissues
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Isolating Stem Cells from Soft Musculoskeletal Tissues

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Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
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Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

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Main Results:

  • Markedly elevated G-CSFR expression was observed in the skeletal muscle developing area.
  • G-CSFR was transiently expressed in regenerating myocytes of adult injured skeletal muscle.
  • Exogenous G-CSF administration supported both short-term and long-term muscle regeneration in mice.

Conclusions:

  • G-CSFR is implicated in skeletal muscle regeneration processes.
  • G-CSF signaling may represent a therapeutic target for enhancing muscle repair.