Related Experiment Video
Updated: Mar 2, 2026
09:59
Preparation of Exosomes for siRNA Delivery to Cancer Cells
Published on: December 5, 2018
26.2K
[Multilateral Strategies Utilizing Exosomes for Cancer Therapy]
Nao Nishida-Aoki1, Takahiro Ochiya
1Division of Molecular and Cellular Medicine, National Cancer Center Research Institute.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|May 25, 2017
Summary
Antibodies can disrupt cancer-derived exosomes, suppressing cancer metastasis. This finding offers a new strategy for cancer therapy by targeting these vesicles and their role in cancer progression.
Area of Science:
- Cell Biology
- Nanotechnology
- Oncology
Background:
- Exosomes are nano-sized extracellular vesicles involved in intercellular communication.
- Cancer-derived exosomes contribute to tumor progression, invasion, drug resistance, and metastasis.
- Exosomes hold potential for cancer therapy, including drug delivery systems and cancer vaccines.
Purpose of the Study:
- To investigate the therapeutic potential of inhibiting cancer-derived exosome function.
- To evaluate the efficacy of antibody-mediated exosome disruption in suppressing cancer metastasis.
Main Methods:
- Utilized a mouse model of human breast cancer metastasis.
- Administered antibodies to disrupt cancer-derived exosomes.
- Monitored the effect of exosome disruption on lung metastasis.
Main Results:
- Antibody-mediated disruption of cancer-derived exosomes significantly suppressed lung metastasis in a mouse model.
- Demonstrated the feasibility of targeting exosome function for cancer treatment.
Conclusions:
- Targeting cancer-derived exosomes represents a promising therapeutic strategy.
- Further research is needed to confirm safety and optimize exosome-based cancer therapies.
More Related Videos
07:33Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
Published on: September 19, 2025
895
11:15A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.7K
Related Concept Videos
01:36Overview of Exosomes
3.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
02:49Cancer Therapies
10.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.3K
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
02:40Cancer Stem Cells and Tumor Maintenance
6.2K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.2K