Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A narrative review of house dust mite allergy: species distribution and allergen sensitisation patterns across tropical regions.

Frontiers in allergy·2026
Same author

Structure-guided development of an electrochemical aptasensor for Salmonella Typhi HlyE antigen detection using in silico and experimental approaches.

Scientific reports·2026
Same author

MicroRNAs as diagnostic biomarkers in periodontitis: a systematic review and meta-analysis.

Odontology·2026
Same author

Beyond traditional diagnosis: aptamer-based microRNA detection for the early diagnosis of periodontitis.

Molecular biology reports·2025
Same author

Binding characterization of small protein-conjugated ssDNA aptamer to recombinant human ICAM-1.

Nucleosides, nucleotides & nucleic acids·2025
Same author

Aptamer based immunotherapy: a potential solid tumor therapeutic.

Frontiers in immunology·2025

Related Experiment Video

Updated: Mar 2, 2026

A Multi-detection Assay for Malaria Transmitting Mosquitoes
09:00

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

13.7K

Aptamer Technology: Adjunct Therapy for Malaria.

Nik Abdul Aziz Nik Kamarudin1, Nurul Adila Mohammed2, Khairul Mohd Fadzli Mustaffa3

  • 1Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Health Campus, Kubang Kerian, 16150 Kelantan, Malaysia. nkabdaziz@gmail.com.

Biomedicines
|May 25, 2017
PubMed
Summary

Aptamer technology offers a novel approach to combat severe malaria by targeting infected red blood cells. This innovative adjunct therapy could reduce mortality rates in malaria-endemic regions.

Keywords:
Plasmodium falciparumadjunct therapyaptamercytoadherencemalaria

More Related Videos

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
10:27

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Published on: November 10, 2015

12.2K
Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.9K

Related Experiment Videos

Last Updated: Mar 2, 2026

A Multi-detection Assay for Malaria Transmitting Mosquitoes
09:00

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

13.7K
Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
10:27

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Published on: November 10, 2015

12.2K
Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.9K

Area of Science:

  • Parasitic diseases
  • Biotechnology
  • Drug discovery

Background:

  • Malaria is a severe parasitic infection, particularly dangerous for young children, pregnant women, and immunocompromised individuals.
  • Cytoadherence of infected erythrocytes (IEs) to endothelial receptors causes IE accumulation in vital organs, leading to severe malaria.
  • Current malaria treatments require novel adjunct therapies to reduce high mortality rates.

Purpose of the Study:

  • To explore the potential of aptamer technology as a new adjunct therapy for severe malaria.
  • To investigate aptamers as anti-adhesive agents against infected erythrocytes.

Main Methods:

  • Review of existing literature on malaria pathogenesis and cytoadherence.
  • Exploration of aptamer selection and application strategies.
  • Analysis of aptamer-based therapeutic potential for malaria.

Main Results:

  • Aptamers can be engineered to bind specifically to infected erythrocytes.
  • Aptamer-based anti-adhesion strategies show promise in preventing IE accumulation.
  • This approach could complement existing malaria treatments.

Conclusions:

  • Aptamer technology presents a promising avenue for developing novel anti-malarial adjunct therapies.
  • Targeting IE cytoadherence with aptamers could mitigate severe malaria complications.
  • Further research into aptamer development is warranted for malaria treatment.