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Toll-like receptor 2 and type 2 diabetes
Zahra Sepehri1, Zohre Kiani2,3, Ali Akbar Nasiri4
1Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Cellular & Molecular Biology Letters
|May 25, 2017
Summary
Toll-like receptor 2 (TLR2) is implicated in type 2 diabetes pathogenesis. This review explores TLR2
Area of Science:
- Immunology
- Endocrinology
- Metabolic Diseases
Background:
- Innate immunity significantly contributes to type 2 diabetes (T2D) and its complications.
- Toll-like receptors (TLRs) are key components of innate immunity, suggesting their involvement in T2D.
- TLR2, activated by damage-associated molecular patterns (DAMPs), is a potential mediator in T2D progression.
Purpose of the Study:
- To review the critical roles and current understanding of TLR2 in type 2 diabetes.
- To examine the involvement of TLR2 in the pathogenesis and complications of T2D.
Main Methods:
- Literature review of recent research on TLR2 and type 2 diabetes.
- Analysis of studies investigating TLR2 activation by DAMPs in the context of T2D.
Main Results:
- TLR2 homodimers and heterodimers (with TLR1 or TLR6) activate innate immunity.
- DAMPs, released during T2D, can trigger TLR2-mediated inflammatory responses.
- Evidence suggests a significant role for TLR2 in the progression of T2D.
Conclusions:
- TLR2 is a key player in the innate immune response relevant to type 2 diabetes.
- Further research into TLR2's function may reveal therapeutic targets for T2D and its complications.
Keywords:
Activator protein 1ComplicationDAMPInnate immunityLeucine-rich repeatsMYD88NF-kBPAMPTLR2Type 2 diabetesMore Related Videos
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