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In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
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BAG2 structure, function and involvement in disease.

Lixia Qin1,2, Jifeng Guo2, Qian Zheng1

  • 1Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.

Cellular & Molecular Biology Letters
|May 25, 2017
PubMed
Summary
This summary is machine-generated.

Bcl2-associated athanogene 2 (BAG2) functions as a co-chaperone, interacting with heat shock protein 70 and regulating cellular processes. BAG2 is implicated in the pathogenesis of cancers and neurodegenerative diseases like Alzheimer's and Parkinson's.

Keywords:
Alzheimer’s diseaseBAG2CarcinomaMolecular chaperonesParkinson’s diseaseSpinocerebellar ataxia type-3

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Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Neuroscience

Background:

  • Bcl2-associated athanogene 2 (BAG2) is a co-chaperone protein within the BAG family.
  • BAG2 interacts with heat shock protein 70 (Hsp70) via its BAG domain and influences numerous cellular functions.
  • Emerging evidence links BAG2 to the development of various diseases, notably cancers and neurodegenerative conditions.

Purpose of the Study:

  • To provide a comprehensive review of BAG2's structure, functions, and protein interactions.
  • To explore the involvement of BAG2 in the pathogenesis of significant human diseases.
  • To highlight the potential of BAG2 as a therapeutic target.

Main Methods:

  • Literature review and synthesis of existing research on BAG2.
  • Analysis of studies detailing BAG2's molecular interactions and cellular roles.
  • Examination of evidence connecting BAG2 to disease mechanisms.

Main Results:

  • BAG2 acts as a co-chaperone, modulating Hsp70 activity and interacting with diverse molecular partners.
  • BAG2 plays a role in cellular homeostasis and stress responses.
  • BAG2 is implicated in the pathogenesis of cancers, Alzheimer's disease, Parkinson's disease, and spinocerebellar ataxia type-3.

Conclusions:

  • BAG2 is a multifaceted protein with critical roles in cellular regulation.
  • Understanding BAG2's function is crucial for elucidating disease pathogenesis.
  • Targeting BAG2 may offer novel therapeutic strategies for cancer and neurodegenerative disorders.