Related Experiment Video
Updated: Mar 2, 2026

Author Spotlight: Developing Precise and Clinically Relevant Models for Studying Secondary Degeneration in Traumatic Optic Neuropathy
Published on: November 29, 2024
Integrated Stress Response as a Therapeutic Target for CNS Injuries
Lorenzo Romero-Ramírez1, Manuel Nieto-Sampedro1,2, M Asunción Barreda-Manso3
1Unidad de Neurología Experimental, Hospital Nacional de Parapléjicos (SESCAM), Finca la Peraleda s/n, 45071 Toledo, Spain.
Abstract:
Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with encouraging potential as therapeutic target for CNS injury repair. In this review, we will focus on the progress in understanding the role of the ISR and we will discuss the effects of various small molecules that target the ISR on different animal models of CNS injury.
More Related Videos
09:29Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
Published on: July 10, 2019
08:20Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
Published on: January 18, 2021
Related Concept Videos
Stress Response System
Alarm stage
In the alarm stage, the body's...
Introduction to Stress and Lifestyle
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...