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Synthesis of 24-heteroatom-substituted cholestanols
M D Rahman1, H M Seidel, R A Pascal
1Department of Chemistry, Princeton University, NJ 08544.
Journal of Lipid Research
|November 1, 1988
Abstract:
Short syntheses of 24-thia-5 alpha,20 xi-cholestan-3 beta-ol, 24-methyl-24-aza-5 alpha,20 xi-cholestan-3 beta-ol, and 24-nor-5 alpha,20 xi-cholan-3 beta-ol from 3 beta-hydroxy-5 alpha-pregnan-20-one are described. The products and synthetic intermediates have been fully characterized by the results of proton NMR, infrared, and high and low resolution mass spectral studies.