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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Multivariate Chiral Covalent Organic Frameworks with Controlled Crystallinity and Stability for Asymmetric Catalysis
Jie Zhang1, Xing Han1, Xiaowei Wu1
1State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , Shanghai 200240, China.
Journal of the American Chemical Society
|May 25, 2017
Summary
Researchers developed a new method for creating chiral covalent organic frameworks (CCOFs) with tunable stability and crystallinity for asymmetric catalysis, achieving high selectivity in key reactions.
Area of Science:
- Materials Science
- Organic Chemistry
- Catalysis
Background:
- Covalent organic frameworks (COFs) offer a modular platform for functional materials.
- Synthetic control over COF chirality remains underexplored.
- Chiral COFs (CCOFs) are promising for asymmetric catalysis.
Purpose of the Study:
- To develop a multivariate strategy for synthesizing chiral COFs (CCOFs).
- To achieve controlled crystallinity and stability in CCOFs for asymmetric catalysis.
- To investigate the impact of catalyst loading on CCOF properties.
Main Methods:
- A multivariate strategy involving the crystallization of triamines and dialdehydes with chiral organocatalysts.
- Preparation of two- and three-component 2D porous CCOFs with different stacking modes.
- Tuning organocatalyst content within the COF structure.
Main Results:
- Successfully synthesized a family of 2D porous CCOFs with controlled chirality, crystallinity, and stability.
- Ternary CCOFs exhibited enhanced crystallinity and stability compared to binary counterparts.
- Ternary CCOFs demonstrated high efficiency as heterogeneous catalysts in asymmetric aminooxylation, aldol, and Diels-Alder reactions, with selectivity rivaling homogeneous catalysts.
Conclusions:
- A novel synthetic route for CCOFs with tunable properties was established.
- The study provides a method for controlling COF crystallinity and stability through component tuning.
- Developed CCOFs show significant potential for heterogeneous asymmetric catalysis.
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