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Pesticide Interactions: Mechanisms, Benefits, and Risks
1Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California , Berkeley, California 94720, United States.
Journal of Agricultural and Food Chemistry
|May 25, 2017
Summary
Pesticide interactions at molecular targets and detoxification systems influence effectiveness and safety. Understanding these mechanisms offers new pest control strategies but requires careful management of complex biological systems.
Area of Science:
- Environmental science
- Biochemistry
- Toxicology
Background:
- Pesticide interactions at molecular targets and detoxification systems are critical for efficacy and safety.
- Compounds with shared modes of action can lead to cross-resistance, necessitating new discovery research.
- Detoxification systems play a key role in pesticide interactions, including cross-resistance, synergism, and safening.
Purpose of the Study:
- To explore the mechanistic aspects of pesticide interactions.
- To highlight the role of detoxification systems in pesticide interactions.
- To discuss the benefits and risks associated with pesticide interactions.
Main Methods:
- Review of existing literature on pesticide interactions.
- Focus on mechanistic details of interactions with detoxification systems (e.g., serine hydrolases, cytochrome P450, glutathione S-transferases).
- Consideration of secondary targets like aldehyde dehydrogenases and transporters.
Main Results:
- Pesticide interactions can lead to cross-resistance and synergist/safener effects.
- Examples include serine hydrolase inhibitors, cytochrome P450 inhibitors, and glutathione S-transferase modulators.
- Secondary targets also influence interaction outcomes.
Conclusions:
- Understanding pesticide interactions provides additional chemical control levels for desired effects.
- Unpredictable interactions in complex biological systems pose risks.
- Careful consideration of mechanisms can optimize the benefits of pesticide combinations.
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