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Updated: Mar 1, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
Science is 1% inspiration and 99% biomarkers
Nicolas Dubuisson1, Fabiola Puentes1, Gavin Giovannoni1
1Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.
Abstract:
Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process. Here, we describe six promising neurodegenerative biomarkers in MS (neurofilament proteins, neurofilament antibodies, tau, N-acetylaspartate, chitinase and chitinase-like proteins and osteopontin), critically evaluating the evidence using a modified Bradford Hill criteria.
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