An update on lupus animal models

Area of Science:

• Immunology
• Rheumatology
• Translational Medicine

Background:

• Systemic lupus erythematosus (SLE) presents complex clinical features, making direct patient research challenging.
• Mouse models are essential for investigating SLE's cellular and genetic underpinnings.
• These models facilitate the identification of therapeutic targets and the screening of potential treatments.

Purpose of the Study:

• To review major spontaneous and induced mouse models of SLE.
• To update on key advances contributed by these models to SLE research.
• To highlight the utility of mouse models in preclinical SLE studies.

Main Methods:

• Review of spontaneous mouse models of SLE.
• Review of induced mouse models of SLE.
• Analysis of contributions of various models to understanding SLE pathogenesis and treatment.

Main Results:

• Mouse models have advanced the understanding of cellular, signaling, and metabolic pathways in SLE.
• Targeting these pathways in models has identified potential therapeutic strategies.
• The review discusses the advantages of specific models for testing particular hypotheses.

Conclusions:

• Spontaneous and induced SLE mouse models are valuable tools for etiological studies and preclinical research.
• Each model offers unique attributes that can be tailored to specific research needs.
• These models are instrumental in identifying therapeutic targets and screening treatments for SLE.