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Precision medicine in pediatric rheumatology
Joo Guan Yeo1, Chin Teck Ng, Salvatore Albani
1aSingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd. bDivision of Medicine, KK Women's and Children's Hospital cDepartment of Rheumatology and Immunology, Singapore General Hospital dDuke-NUS Medical School, Singapore, Singapore.
Current Opinion in Rheumatology
|May 25, 2017
Summary
Precision medicine in pediatric rheumatology requires defining disease subtypes by molecular profiles. Addressing unmet needs through data integration will improve treatment strategies and patient outcomes.
Area of Science:
- Pediatric Rheumatology
- Immunology
- Precision Medicine
Background:
- Current classification of pediatric rheumatic diseases lacks prognostic and therapeutic selection information.
- Molecular differences exist between disease subtypes and among patients with the same disease.
- Holistic interrogation of multifactorial rheumatic diseases requires collaboration across research networks.
Purpose of the Study:
- Summarize unmet needs in pediatric rheumatology for precision medicine.
- Highlight the importance of molecular immunological profiles for disease subcategorization.
- Discuss considerations for therapeutic strategies including growth, puberty, and developmental changes.
Main Methods:
- Review of current literature on pediatric rheumatology and precision medicine.
- Analysis of unmet needs in disease classification and prognostication.
- Exploration of data integration strategies using high-dimensional technologies.
Main Results:
- Existing clinical classifications are insufficient for precise prognostication and treatment selection.
- Significant molecular heterogeneity exists within and between pediatric rheumatic diseases.
- Collaboration and data sharing are crucial for understanding disease complexity.
Conclusions:
- Integrating big data from well-defined pediatric cohorts is essential for elucidating disease mechanisms.
- Accurate disease stratification through data analysis will improve prognosis and treatment choices.
- Precision medicine approaches promise to enhance patient care in pediatric rheumatology.
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