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[Comparative analysis of different methods of geroprotective]
V S Myakotnykh1, M N Torgashov1, K V Egorin1
1Ural state medical University, Ekaterinburg, 620028, Russian Federation; vmaykotnykh@yandex.ru.
This study compared geroprotective methods, finding that combined Oligopeptide complexes (Vezugen and Pinealon) most effectively improved biological age indicators. Therapeutic massage and Oligopeptides were safest, while CO2 baths and hyperbaric oxygen had safety limitations.
Area of Science:
- Gerontology
- Biochemistry
- Immunology
Background:
- Aging is associated with various physiological declines.
- Geroprotective techniques aim to mitigate aging processes and improve healthspan.
- Oligopeptide complexes show potential in modulating age-related changes.
Purpose of the Study:
- To comparatively analyze the efficacy and safety of various geroprotective interventions.
- To evaluate the impact of Oligopeptide preparations (Vezugen, Pinealon) on biological age.
- To assess the safety profiles of different anti-aging therapies.
Main Methods:
- Comparative analysis involving 110 participants across different age groups.
- Assessment of geroprotective techniques: dry carbon dioxide baths, hyperbaric oxygen therapy, therapeutic massage, and Oligopeptide administration.
- Monitoring of biochemical, immunological, and clinical parameters, alongside biological age indicators.
Main Results:
- Combined use of lysyl-glutamyl-asparagin and glutamyl-asparagin-arginine Oligopeptide complexes demonstrated the most significant positive effect on biological age.
- Therapeutic massage and Oligopeptide drugs exhibited the highest safety profile concerning biochemical, immunological, and clinical parameters.
- Dry carbon dioxide baths and hyperbaric oxygenation, while beneficial for biological age, presented notable limitations and contraindications.
Conclusions:
- Combined Oligopeptide therapy offers a promising approach for enhancing biological age indicators.
- Therapeutic massage and Oligopeptides represent safe geroprotective options.
- Careful consideration of safety limitations is crucial when employing dry carbon dioxide baths and hyperbaric oxygen therapy.
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