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[Platelet functional activity in clinically healthy elderly].

I N Medvedev1

  • 1Kursk Institute of Social Education (branch) of Russian State Social University, Kursk, 305029, Russian Federation; ilmedv1@yandex.ru.

Advances in Gerontology = Uspekhi Gerontologii
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Summary

Platelet aggregation increases with age in healthy elderly individuals, alongside reduced antioxidant protection and heightened lipid peroxidation. This age-related platelet hyperactivity may contribute to cardiovascular disease risk.

Keywords:
aggregationintravascular platelet activityold ageontogenesisplatelets

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Area of Science:

  • Gerontology
  • Cardiovascular Science
  • Biochemistry

Background:

  • Platelet aggregation plays a crucial role in hemostasis and thrombosis.
  • Age-related physiological changes can impact cardiovascular health.
  • Understanding platelet function in healthy aging is vital for disease prevention.

Purpose of the Study:

  • To investigate platelet aggregation in clinically healthy elderly individuals.
  • To assess the relationship between aging, antioxidant status, lipid peroxidation, and platelet activity.
  • To explore the implications of these changes for cardiovascular disease risk.

Main Methods:

  • Study included 121 clinically healthy elderly individuals (61-74 years) with no history of metabolic, cancer, or cardiovascular disease.
  • Assessed antioxidant protection and lipid peroxidation levels.
  • Measured in vitro and in vivo platelet aggregation using various inducers.
  • Monitored blood levels of activated platelets and circulating platelet aggregates.

Main Results:

  • Healthy elderly subjects exhibited weakened antioxidant protection and increased lipid peroxidation.
  • Platelet aggregation showed a significant age-dependent increase both in vitro and in vivo.
  • Elevated levels of activated platelets and circulating aggregates were observed with increasing age.
  • These findings suggest a pro-thrombotic shift in platelet function with aging.

Conclusions:

  • Increased platelet activity in healthy aging, coupled with reduced antioxidant capacity, contributes to a higher risk profile for cardiovascular diseases.
  • Age-related changes in platelet function are significant even in the absence of overt disease.
  • These alterations may be exacerbated by subclinical conditions and environmental factors, increasing cardiovascular risk.