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Updated: Mar 1, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

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A QSAR classification model for neuraminidase inhibitors of influenza A viruses (H1N1) based on weighted penalized

Z Y Algamal¹, M K Qasim², H T M Ali³

¹a Department of Statistics and Informatics , University of Mosul , Mosul , Iraq.

SAR and QSAR in Environmental Research

|May 26, 2017

Abstract:

Descriptor selection is a procedure widely used in chemometrics. The aim is to select the best subset of descriptors relevant to the quantitative structure-activity relationship (QSAR) study being considered. In this paper, a new descriptor selection method for the QSAR classification model is proposed by adding a new weight inside L1-norm. The experimental results from classifying the neuraminidase inhibitors of influenza A viruses (H1N1) demonstrate that the proposed method in the QSAR classification model performs effectively and competitively compared with other existing penalized methods in terms of classification performance and the number of selected descriptors.

Keywords:

Penalized support vector machine Wilcoxon rank sum test descriptor selection influenza A viruses lasso

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