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Updated: Mar 1, 2026

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp
Tu Cam Le1, Chae-Yoon Yim1, Songhee Park2
1Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea.
Abstract:
HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A-C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).
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