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Updated: Mar 1, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Update on neuromyelitis optica: natural history and management
Panitha Jindahra1,2, T Plant1,2
1The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Abstract:
Neuromyelitis optica or Devic disease is an inflammatory disorder of the central nervous system. It is caused by antibodies that attack aquaporin 4 water channels in the cell membrane of astrocytic foot processes at the blood brain barrier. It can involve the optic nerve, the spinal cord and beyond. Here we review its pathophysiology, clinical features, and therapy.
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